The benefits of Resveratrol for your skin

November 30, 2019

Resveratrol & Skin Health

Resveratrol is an ideal ingredient for use in ‘Beauty from Within’ products, topical creams and serum applications.

Skin health, a matter of protection Pollution as well as unhealthy habits (poor nutrition, sun-bathing and smoking) can contribute to the development of oxidative stress and damage our skin. This can cause age spots, wrinkles, and even chronic inflammation, giving skin a prematurely aged look.

Ref : Poljšak B and Dahmane R. Free Radicals and Extrinsic Skin Aging. Dermatol Res Pract. 2012, 135206 (2012).

Resveratrol’s antioxidant and anti-inflammatory properties can contribute to the preservation of healthier and younger looking skin.

Ref: Farris, P. et al. Resveratrol : A Unique Antioxidant Offering a Multi-Mechanistic Approach for Treating Aging Skin. J Drugs Dermatol. 12, 1389-1394. (2013).

Oral use of resveratrol blend shows anti-ageing effects in skin.

Antioxidant properties of resveratrol and its effect on skin health has been the topic of many discussions.(a) A placebo controlled, double-blind study (b) showed that resveratrol:

Significantly decreased systemic oxidative stress and increased plasmatic antioxidant capacity, and skin antioxidant power
Improved skin moisturisation and elasticity
Diminished skin roughness and depth of wrinkles
Significantly decreased intensity of age spots.

50 individuals between 35 - 65 years, Sixty days, blend containing 8 milligrams of resveratrol and other ingredients.

Ref (a): Farris, P. et al. Resveratrol : A Unique Antioxidant Offering a Multi-Mechanistic Approach for Treating Aging Skin. J Drugs Dermatol. 12, 1389-1394. (2013).

Ref (b) : Buonocore, D. et al. Resveratrol-procyanidin blend: nutraceutical and antiaging efficacy evaluated in a placebo-controlled, double-blind study. Clin Cosmet Investig Dermatol. 5, 159–165 (2012).

Research indicates resveratrol may promote skin whitening.

Resveratrol has several intra-cellular targets that mediate its biological effects.

Ref: Britton, R. G., Kovoor, C. and Brown, K. Direct molecular targets of resveratrol : identifying key interactions to unlock complex mechanisms. Ann N Y Acad Sci. 1348, 124–133 (2015).

Among these targets, resveratrol binds and inhibits the activity of tyrosinase, a key enzyme involved in melanogenesis.

Ref: Bernard, P. and Berthon, J. Resveratrol : an original mechanism on tyrosinase inhibition. Int J Cosmet Sci. 22, 219–226 (2000).

A study in an animal model analysed the effects of topical resveratrol in UVB-induced pigmentation and indicated resveratrol:

Ref: Lee, T. H. et al. Inhibitory Effects of Resveratrol on Melanin Synthesis in Ultraviolet B-Induced Pig mentation in Guinea Pig Skin. Biomol Ther (Seoul). 22, 35-40 (2014).

Inhibits melanin synthesis by inhibiting tyrosinase and other enzymes
Significantly decreases pigmentation in skin .
Could be used to treat skin disorders such as hyperpigmentation and skin photo-ageing e.g. age spots.

Resveratrol helps to reduce acne

As with other polyphenols, resveratrol has some mild antimicrobial properties. Unlike other polyphenols, resveratrol has been shown to be particularly active against several acne-forming strains.(C),(d)

Ref ( C) : Coenye, T. et al. Eradication of Propionibacterium acnes biofilms by plant extracts and putative identification of icariin, resveratrol and salidroside as active compounds. Phytomedicine. 19, 409–412 (2012).

Ref: (d) : Kim, S. O. Y. et al. Resveratrol exerts growth inhibitory effects on human SZ95 sebocytes through the inactivation of the PI3-K / Akt pathway. Int J Mol Med. 35, 1042–1050 (2015).

A single-blind, vehicle-controlled, pilot study using a resveratrol-containing hydrogel for the treatment of acne vulgaris showed that resveratrol:

Ref: Fabbrocini, G. and Study, P. Resveratrol-Containing Gel for the Treatment of Acne Vulgaris Resveratrol-Containing Gel for the Treatment of Acne Vulgaris. Am J Clin Dermatol. 12,133-141 (2011).

Produced a 53.75 Percent mean reduction in the Global Acne Grading System (GAGS) score
Reduced the average area of microcomedones by 66.7 Percent (little plugs, first sign of acne)

20 individuals affected by acne, 60 days, ~0.01% w/v - only right side of the face

Study suggests the possible impact of resveratrol on psoriasis

Resveratrol’s anti-inflammatory properties was recently the subject of a review paper.

Ref: Poulsen, M. M. et al. Resveratrol and inflammation: Challenges in translating pre-clinical findings to improved patient outcomes. Biochimica et Biophysica Acta 1852, 1124–1136 (2015).

A recent animal study that analysed the protective effects of resveratrol against induced psoriasis-like skin inflammation. The study showed that resveratrol:

Ref:: Kjær, T. et al. Resveratrol Ameliorates Imiquimod-Induced Psoriasis-Like Skin Inflammation in Mice. PLoS One. 10, 1–18 (2015)

Induced the expression of genes associated with retinoic acid stimulation and reduced expression of certain pro-inflammatory cytokine genes that are central in developing psoriasis
Reduced skinfold thickening
Improved erythema (red skin) and scaling scores

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